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The literature was interpreted using four evidence categories: Direct AOD9604 evidence: endpoints measured in an experiment that clearly identified the tested material as AOD9604

insulin sensitizer with hepatic benefits and modest weight effects (Rubio et al., 2020) Contraception: Initiate combined oral contraceptive (COC) to stabilize cycles and prevent unplanned pregnancy

doi: 10.1007/s12013-020-00905-6 273

National Library of Medicine (PubMed)

every other arm, including the slow 12 mg ladder, peaked and then settled into single digits. GIP activates an anti-nausea circuit, but that adaptation needs several weeks alongside a lower GLP-1 load